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A Practical Guide to the \"Classic\" (C‑D) Cycle

(Conjugated Estradiol – Estradiol)



> Disclaimer:

> This guide is for educational purposes only and does not constitute medical advice. The information below reflects typical practices observed in the bodybuilding community; actual dosing, cycle length, and monitoring should be tailored by a qualified healthcare professional based on individual health status.



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1. What Is the C‑D Cycle?



Component Typical Dose (per week) Key Role


Conjugated Estradiol (C‑E) 5 mg – 10 mg Provides estrogenic activity, helps maintain libido and overall well‑being.


Dianabol (Methandrostenolone, D‑B) 20 mg – 30 mg An oral anabolic steroid that boosts protein synthesis, nitrogen retention, and glycogen storage—great for short‑term bulking phases.






Why combine them?


Dianabol alone can cause mood swings, increased aggression, or estrogenic side effects (gynecomastia). Adding C‑E helps to balance the hormonal milieu, potentially moderating these adverse reactions while preserving the anabolic benefits.





? Scientific Rationale & Evidence



Compound Primary Mechanism of Action Key Findings in Human Studies


Cimetidine (Cimet) Histamine H2 receptor antagonist → ↓ gastric acid secretion; also modestly blocks aromatase and 5α‑reductase. Limited data on hormonal effects, but some case reports suggest decreased estradiol levels in men taking high doses.


Cimetidine + Estradiol (E) Combined anti‑estrogenic effect via cimetidine’s aromatase inhibition plus exogenous estradiol to modulate feedback loops. Small studies in post‑menopausal women show reduction in breast density and potential anti‑cancer effects.


Cimetidine + Estradiol (E) + Progesterone (P) Adds progestogenic activity, countering estrogen’s proliferative effect on endometrium; may enhance tamoxifen-like action. Limited data; some trials suggest improved breast cancer prevention outcomes in high‑risk women.


Tamoxifen (T) Selective Estrogen Receptor Modulator (SERM); antagonistic in breast tissue, agonistic in bone and uterus. Widely used for breast cancer prevention and treatment; risk of endometrial hyperplasia.


> Key Insight: Adding progester